LABEX PUBLICATIONS 2018

Immunological characterization of a rat model of Duchenne's disease and demonstration of improved muscle strength after anti-CD45RC antibody treatment

L.-H. Ouisse, S. Rémy, A. Lafoux, T. Larcher, L. Tesson, V. Chenouard, C. Guillonneau, L. Brusselle, N. Vimond, K. Rouger, Y. Péréon, A. Chenouard, C. Gras-Le Guen, C. Braudeau, R. Josien, C. Huchet, I. Anegon

BioRxiv Sept 2018 - Download full text

Merkel cell carcinoma and cellular cytotoxicity: sensitivity to cellular lysis and screening for potential target antigens suitable for antibodydependent cellular cytotoxicity

Jocelyn Ollier, Thibault Kervarrec, Mahtab Samimi, Houssem Benlalam, Pascal Aumont, Régine Vivien, Antoine Touzé, Nathalie Labarrière, Henri Vié, Béatrice Clémenceau

Cancer Immunology, Immunotherapy May 2018 - Download full text

Thoracic and cutaneous sarcoid-like reaction associated with anti-PD-1 therapy:longitudinal monitoring of PD-1 and PD-L1 expression after stopping treatment

Léa Paolini, Caroline Poli, Simon Blanchard, Thierry Urban, Anne Croué, Marie-Christine Rousselet,Sarah Le Roux, Nathalie Labarrière, Pascale Jeannin and José Hureaux

Journal for ImmunoTherapy of Cancer (2018) 6:52 - Download full text

Regulation of the immune response by the inflammatory metabolic microenvironment in the context of allotransplantation

N. Degauque, C. Brosseau, S. Brouard

Frontiers in immunology, June 2018

   

Advances on CD8+ Tregs and their potential in transplantation

Bézie S1,2,3, Anegon I1,2,3, Guillonneau C

Transplantation. 2018 Apr 24.

 

An intermediate level of CD161 expression defines a novel activated, inflammatory, and pathogenic subset of CD8+ T cells involved in multiple sclerosis

Nicol B, Salou M, Vogel I, Garcia A, Dugast E, Morille J, Kilens S, Charpentier E, Donnart A, Nedellec S, Jacq-Foucher M, Le Frère F, Wiertlewski S, Bourreille A, Brouard S, Michel L, David L, Gourraud PA, Degauque N, Nicot AB, Berthelot L, Laplaud DA

J Autoimmun. 2018 Mar;88:61-74 - Download full text  

 

Association of Defective Regulation of Autoreactive Interleukin-6-Producing Transitional B Lymphocytes With Disease in Patients With Systemic Sclerosis

Taher TE, Ong VH, Bystrom J, Hillion S, Simon Q, Denton CP, Pers JO, Abraham DJ, Mageed RA

Arthritis Rheumatol. 2018 Mar;70(3):450-461 - Download full text  

 

B cell subset distribution is altered in patients with severe periodontitis

Demoersman J, Pochard P, Framery C, Simon Q, Boisramé S, Soueidan A, Pers JO

PLoS One. 2018 Feb 15;13(2):e0192986 - Download full text  

 

B cells in operational tolerance

Chesneau M, Danger R, Soulillou JP, Brouard S

Hum Immunol. 2018 May;79(5):373-379 - Download full text  

 

Increased degradation of ATP is driven by memory regulatory T cells in kidney transplantation tolerance

Durand M, Dubois F, Dejou C, Durand E, Danger R, Chesneau M, Brosseau C, Guerif P, Soulillou JP, Degauque N, Eliaou JF, Giral M, Bonnefoy N, Brouard S

Kidney Int. 2018 May;93(5):1154-1164

 

The roles of CSFs on the functional polarization of tumor-associated macrophages

Jeannin P, Paolini L, Adam C, Delneste Y

FEBS J. 2018 Feb;285(4):680-699 - Download full text  

 

Impact on early outcomes and immune reconstitution of high-dose post-transplant cyclophosphamide vs anti-thymocyte globulin after reduced intensity conditioning peripheral blood stem cell allogeneic transplantation

Retière C, Willem C, Guillaume T, Vié H, Gautreau-Rolland L, Scotet E, Saulquin X, Gagne K, Béné MC, Imbert BM, Clemenceau B, Peterlin P, Garnier A, Chevallier P

Oncotarget. 2018 Jan 27;9(14):11451-11464 - Download full text  

 

HLA-DR expression in neonates after cardiac surgery under cardiopulmonary bypass: a pilot study

Chenouard A, Braudeau C, Cottron N, Bourgoin P, Salabert N, Roquilly A, Josien R, Joram N, Asehnoune K

Intensive Care Med Exp. 2018 Jan 11;6(1):1 - Download full text  

 
 

Blood Gene Expression Predicts Bronchiolitis Obliterans Syndrome

Danger R, Royer PJ, Reboulleau D, Durand E, Loy J, Tissot A, Lacoste P, Roux A, Reynaud-Gaubert M, Gomez C, Kessler R, Mussot S, Dromer C, Brugière O, Mornex JF, Guillemain R, Dahan M, Knoop C, Botturi K, Foureau A, Pison C, Koutsokera A, Nicod LP, Brouard S, Magnan A; COLT and SysCLAD Consortia

Front Immunol. 2018 Jan 11;8:1841. - Download full text  

 

Fate of transplanted lungs is controlled by immune cells encounter within pulmonary allografts

Degauque N

Am J Transplant. 2018 Jan;18(1):9-10 - Download full text  

Breakdown of immune tolerance in AIRE-deficient rats induces a severe APECED-like auto-immune disease

Jason Ossart, Anne Moreau, Elodie Autrusseau, Séverine Ménoret, Jérôme C. Martin, Marine Besnard, Laure-Hélène Ouisse, Laurent Tesson, Léa Flippe, Kai Kisand, Pärt Peterson, François-Xavier Hubert, Ignacio Anegon, Régis Josien and Carole Guillonneau

J. Immunol. , July 2018

 

HCMV triggers frequent and persistent UL40-specific unconventional HLA-E-restricted CD8 T-cell responses with potential autologous and allogeneic peptide recognition

N. Jouand, C. Bressollette-Bodin, N. Gérard, M. Giral, P. Guérif, A. Rodallec, R. Oger, T. Parrot, M. Allard, A. Cesbron-Gautier, N. Gervois and B. Charreau

PLOS Pathogens  April 30, 2018 - Download full text  

Comparison of Immuno-PET of CD138 and PET imaging with 64CuCl2 and 18F-FDG in a preclinical syngeneic model of multiple myeloma

Clément Bailly, Sébastien Gouard, Marie Lacombe, Patricia Remaud-Le Saëc, Benjamin Chalopin, Mickaël Bourgeois, Nicolas Chouin, Raphaël Tripier, Zakaria Halime, Ferid Haddad, Alain Faivre-Chauvet, Françoise Kraeber-Bodéré, Michel Chérel and Caroline Bodet-Milin

Oncotarget, Jan 2018 - Download full text

 

Generation of immunodeficient rats with Rag1 and Il2rg gene deletions and human tissue grafting models

Séverine Ménoret, Laure-Hélène Ouisse, Laurent Tesson, Frédéric Delbos, Delphine Garnier, Séverine Remy, Claire Usal, Jean-Paul Concordet, Carine Giovannangeli, Vanessa Chenouard, Lucas Brusselle, Emmanuel Mérieau, Véronique Nerrière-Daguin, Franck Duteille, Frédérique Bellier-Waast, Alexandre Fraichard, Tuan H. Nguyen and Ignacio Anegon

Transplantation. 2018 Apr 23.  

Fine-mapping the interaction between DC-SIGN and the cytomegalovirus envelope glycoprotein B

C. Chéneau, F. Coulon, V. Porkolab, F. Fieschi, S. Laurant, D. Razanajaona-Doll, J.-J. Pin, E. Maria Borst, M. Messerle, C. Bressollette-Bodin, F. Halary

J Infect Dis. 2018 Apr 10 - Download Full Text

 

Multiplex CRISPR/Cas9 system impairs HCMV replication by excising an essential viral gene

J. Gergen, F. Coulon, A. Creneguy, N. Elain-Duret, A. Gutierrez, O. Pinkenburg,E. Verhoeyen, I. Anegon, T. H. Nguyen, F. A. Halary, F. Haspot

Plos One, Feb 2018 - Download Full Text

 

CtIP fusion to Cas9 enhances transgene integration by homology-dependent repair

M. Charpentier, A. H. Y. Khedher, S. Menoret, A. Brion, K. Lamribet, E. Dardillac, C. Boix, L. Perrouault, L. Tesson, S. Geny, A. De Cian, J. M. Itier, I. Anegon, B. Lopez, C. Giovannangeli & J. P. Concordet

Nature Communications, March 2018 - Download Full Text

   

C-type lectin-like receptors as emerging orchestrators of sterile inflammation represent potential therapeutic targets

E. Chiffoleau

Frontiers in Immunology, Jan 2018

 

Tolerogenic dendritic cells in solid organ transplantation: where do we stand?

E. Marin, M.C. Cuturi, A. Moreau

Frontiers in Immunology, Fev 2018

 
 

Ex vivo expanded human non-cytotoxic CD8+CD45RClow/- tregs efficiently delay skin graft rejection and GVHD in humanized mice

S. Bézie, D. Meistermann, L. Boucault, S. Kilens, J. Zoppi, E. Autrusseau, A. Donnart, V. Nerrière-Daguin, F. Bellier-Waast, E. Charpentier, F. Duteille, L. David, I. Anegon & C. Guillonneau

Frontiers in Immunology, Jan 2018

 
 

C-type lectin-like receptors as emerging orchestrators of sterile inflammation represent potential therapeutic targets

E. Chiffoleau

Frontiers in Immunology, Jan 2018

 

High circulating CD4+CD25hiFOXP3+ T cell subpopulation early after lung transplantation is associated with development of bronciolitis obliterans syndrome

M. Durand, P. Lacoste, R. Danger, L. Jacquemont, C. Brosseau, E. Durand, G. Tilly, J. Loy, A. Foureau, P.-J. Royer, A. Tissot, A. Roux, M. Reynaud-Gaubert, R. Kessler, S. Mussot, C. Dromer, O. Brugière, J.-F. Mornex, R. Guillemain, J. Claustre, N. Degauque, A. Magnan, S. Brouard & COLT and SysCLAD Consortia

J Heart Lung Transplant, 2018 - In press

Parallel derivation of isogenic human primed and naive induced pluripotent stem cells

S. Kilens, D. Meistermann, D. Moreno, C. Chariau, A. Gaignerie, A. Reignier, Y. Lelièvre, M. Casanova, C. Vallot, S. Nedellec, L. Flippe, J. Firmin, J. Song, E. Charpentier, J. Lammers, A. Donnart, N. Marec, W. Deb, A. Bihouée, The Milieu Intérieur Consortium, C. Le Caignec, C. Pecqueur, R. Redon, P. Barrière, J. Bourdon, V. Pasque, M. Soumillon, T. S. Mikkelsen, C. Rougeulle, T. Fréour & L. David

Nat Commun 2018, 9 - Download full text

 

Notch signaling triggered via the ligand DLL4 impedes M2 macrophage differentiation and promotes their apoptosis

S. Pagie, N. Gérard & B. Charreau

Cell Communication and Signaling, Jan 2018 in press

 

A Standardized FlowCytometry Procedure for the Monitoring of Regulatory T Cells in Clinical Trials

F. Pitoiset, M. Barbié, G. Monneret, C. Braudeau, P. Pochard, I. Pellegrin, J. Trauet, M. Labalette, D. Klatzmann, M. Rosenzwajg

Cytometry Part B, 2018 -  - Download full text

PD-1 expression on tumor-specific T cells: Friend or foe for immunotherapy ?

Sylvain Simon and Nathalie Labarriere

OncoImmunology, Volume 7, 2018 - Issue 1 - Download full text